Mixture Design for Optimal Formulations (MIX), $1295

Mixture Design for Optimal Formulations (MIX), $1295

In this 2-day hands-on workshop, formulators learn how to use mixture designs to discover key ingredient combinations that maximize product performance. Then they use optimization to explore their formulations and identify the "sweet spot" where all specifications can be met. Experimenters will: set up mixture-appropriate designs, select representative models, and generate contour plots in triangular space. Later in class, they will move into more advanced techniques to design for constrained mixture variables, optimize product formulas, screen mixture components, and study mixture and process variables.

A 10% discounted Early Bird rate applies to registrations made 6 weeks prior to the workshop date. A $200/person discount is applied for 2 or more attendees registering together. Price includes a $95 fee for workshop materials which is subject to state and local taxes.

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Price: $1,295.00


Mixture Design for Optimal Formulations (MIX) (2 days)

“By far the best DOE class I have had."  —Chemist, MIXC Graduate


The Recipe for Success

If you do product formulation, then standard factorial designs just don't work. You need mixture designs to experiment most effectively. When your work involves both changing the formulation and processing the product, mixture-process combined designs are the optimal tool for success.

“Software, documentation, help and presentations are uniformly excellent!” 
—Research Scientist, MIXC Graduate


Ingredients for Efficient Experimentation

During the Mixture Design for Optimal Formulations workshop you will:

  • Discover what defines a mixture experiment
  • Set up simplex designs
  • Augment and evaluate design quality
  • Select appropriate mixture models
  • Generate contour plots in triangular space
  • Design for constrained mixture variables
  • Optimize product formulas
  • Combine mixture and process variables
  • Deal with hard-to-change factors using split-plot designs
  • Improve process understanding with mixture-amount, mixture-categoric, and combined-mixture designs

“Great class!”  —Principal Scientist, MIXC Graduate


Produce Contour Maps in Mixture Space

Design-Expert® software helps you practice designing and analyzing mixture experiments throughout the workshop. The software provides the power for the generation of optimal designs, as well as sophisticated graphical outputs such as trace plots. You will learn how these methods work and what to look for.

Course Outline

Day 1

Section 1 – Introduction to Mixtures

  • What makes a mixture?
  • Mixture (Scheffé) polynomials
  • Simplex lattice designs: Media

Section 2 – Constrained Mixtures, Simplex

  • Blocking a simplex design: Olive oil
  • ABS pipe
    • Coding: Actual – Real – L_Pseudo
    • Analysis and Model reduction
    • Optimization
      • Numeric
      • Graphical


Section 3 – Constrained Mixtures, Non-Simplex

  • Sizing for precision
  • Constrained mixtures: Extreme vertices
  • Optimal point selection: Hydrophilic tablet
  • Transformations & equation only: Antiseptic
 Day 2

Section 4 – Multicomponent Linear Constraints

  • MLC primer
  • Group constraints: Fruit punch
  • Ratio constraints: Stability

Section 5 – Screening Components

  • Simplex: Gasoline additives
  • Non-simplex screening designs
  Section 6 – Combining Mixture and Process Variables
  • Combined designs
    • Fish patties (background)
    • Fish patties optimal design

Section 7 – Special Mixture and Process Problems

  • KCV model: Combining mixture and process variables
    • Background
    • Example (3M+2P)
  • Mixture amount experiment: Ibruprofen
  • Mixture with categoric factor: Composite material
  • Summary
    • Next steps

Section 8 – Combining Mixture & Process Variables as Split Plots (optional material as time allows)

  • Combined split-plot designs
    • Reverse phase HPLC (split plot - process HTC)
    • Sweet Potate Chips (split plot - mixture HTC)


What if I don’t know whether I need this class?
We encourage you to read our free download, "A Primer on Mixture Design: What’s In It for Formulators?". This introductory text offers formulators modern insights into experimentation on formulations. Learn how mixture designs will meet your needs and produce better results than factorial designs.

Additional Information

PDHs 16 (equals 1.6 CEUs)
Additional Information

Workshop location details will be provided with your confirmation letter, which you will receive once the minimum enrollment requirements are met.

Recommended Texts and Software

Recommended Texts and Software

Purchase the recommended software at the time of registration to receive a 20% discount. Formulation Simplified text may be purchased at a 20% discount in conjunction with the workshop registration. Other recommended texts may be purchased from your favorite bookseller.