This talk provides a briefing on design of experiments (DOE) for rapid and effective screening, characterization and optimization of factors affecting reliability. It covers a broad range of design of experiment (DOE) tools, including factorial design, Weibull regression, split plots for hard-to-change factors and response surface methods (RSM) for minimizing failure rates. Anyone tasked with improving reliability will benefit by learning how to make the most from every experiment via these multifactor testing methods.