Based on decades of DOE experience, this presentation lays out a long list of causes for why experiments fail to produce useful results. It begins with a naïve trust by my chemical engineering professors that first principles, along with a few simple one factor at a time (OFAT) experiments would win the day for industrial R&D. Luckily for me, I got trained on multifactor design of experiments (DOE) from my start as a specialty-chemical process developer. Even so, ‘textbook quality’ DOEs did not come easily for me and I’ve seen far too few of them from clients throughout my long career at Stat-Ease—predating its Incorporation in 1985. Attend this talk to hear the biggest reasons why DOE’s fail and thus learn how to improve your chances for success.