Stat-Ease Blog

Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!

Featured Article

Orange-Fleshed Sweet Potatoes, Grain Amaranth, Biofortified Beans, and Maize Composite Flour Formulation Optimization and Product Characterization
Food Science and Nutrition, Volume 13, Issue 6. June 2025.
Authors: Julius Byamukama, Robert Mugabi, Dorothy Nakimbugwe, John Muyonga

Mark's comments: "It's good to see response surface methods for optimization of food recipes via mixture design. I appreciate publications that include all the data needed to assess the predictive modeling.  Kudus to EU for funding research like this that alleviates malnutrition in vulnerable populations."

Be sure to check out this important study, and the other research listed below!

More new publications from June

1. Optimization and induction effect evaluation of complex inducer of Aquilaria sinensis based on factorial design
   Scientific Reports, volume 15, Article number: 19656 (2025)
   Authors: Qiuyue Ding, Baoyi Qin, Shimin Deng, Jie Chen, Ziwei Liu, Weiping Zhou, Xiaoying Chen, Weimin Zhang, Xin Zhou, Xiaoxia Gao
2. Adsorption of crystal violet using thiazolium ionic liquid-crosslinked alginate hydrogels: Modelling using Box-Behnken experimental design
   International Journal of Biological Macromolecules, Volume 318, Part 1, July 2025, 144951
   Authors: Merve Ceylan, Jülide Hızal, Elif Nur Özer, Ivaylo Tankov, Rumyana Yankova
3. High-Performance Ultrathin Membrane with Molecular Arrangement Ordered for Proton Exchange Membrane
   ACS Applied Polymer Materials, published June 10, 2025
   Authors: Yuqing Zhang, Ailing Zhang, Kaixiang Zhou, Yongjiang Li
4. Impact of addition of polyvinyl chloride on the properties of clayey soil using experimental approach and optimization for geotechnical engineering applications
   Scientific Reports, volume 15, Article number: 19901 (2025)
   Authors: Ghania Boukhatem, Said Berdoudi, Messaouda Bencheikh, Mohammed Benzerara, Mehmet Serkan Kırgız, N. Nagaprasad, Krishnaraj Ramaswamy
5. Copper Corrosion in Blended Diesel-Biodiesel: Corrosion Rate Evaluation and Characterization
   Chemical Engineering & Technology, e70053, 12 June 2025
   Authors: Lekan Taofeek Popoola, Celestine Chidi Nwogbu, Usman Taura, Yuli Panca Asmara, Alfred Ogbodo Agbo, Paul C. Okonkwo
6. The Effects of Novel Thymoquinone-Loaded Nanovesicles as a Promising Avenue to Modulate Autism Associated Dysregulation by Restoring Oxidative Stress in Autism in Mice
   International Journal of Nanomedicine, 24 June 2025 Volume 2025:20 Pages 8041—8061
   Authors: Nermin Eissa, Jana K Alwattar, Petrilla Jayaprakash, Dana Chkier, Aala Osama Ahmed, Anum Ahmed, Rameen Rizwan, Sulthan Mujeeb, Mohamad Rahal, Bassem Sadek

Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!

Featured Article

Enhanced 4-chlorophenol adsorption from aqueous solution using eco-friendly nanocomposite
Ecological Engineering & Environmental Technology, 26(5), pp.174-189
Authors: Fadia A. Sulaiman, Rasha Khalid Sabri Mhemid, Noor A. Mohammed

Mark's comments: It is great to see the application of response surface methods (RSM) to reduce the release of toxic chlorophenols to our environment, particularly via such an eco-friendly process utilizing a natural polymer--xanthan gum.  The 3D graphics are compelling and well supported by the reported statistics.  I also appreciate that all the raw data is including, making it possible for me to reproduce the results.

Be sure to check out this important study, and the other research listed below!

More new publications from May

1. Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
   Drug Design, Development and Therapy, 2025;19:3715-3734
   Authors: Mujtaba MA, Rashid MA, Alhamhoom Y, Gangane P, Jagtap MJ, Akbar MJ, Wathore SA, Kaleem M, Elhassan GO, Khalid M
   
2. Design of Experiments Approach for the Development of a Validated UPLC-Q-ToF/MS Method to Quantitate Soy-Derived Bioactive Peptide Lunasin in Rabbit Plasma: Application to a Pharmacokinetic Study
   Biomedical Chromatography, 2025, 39: e70098
   Authors: Kowmudi, G., Anoop, K., Varshini, M., Nagappan, K., Konanki, S., Praveen, T
   
3. Development of a Stability-Indicating RP-HPLC Method for Pioglitazone in Cubosomal and Biological Matrices: A Quality by Design-Driven, Lean Six Sigma, and Green Chemistry Approach
   Separation Science Plus, 2025, 8: e70055
   Authors: Vaibhavi D. Torgal, Vinayak Mastiholimath, Rahul Koli
   
4. Optimization process of coffee pulp wines combined with the artificial neural network and response surface methodology
   Scientific Reports, volume 15, Article number: 16684 (2025)
   Authors: Rongsuo Hu, Fei Xu, Liyan Zhao, Wenjiang Dong
   
5. Formulation optimization of furosemide floating-bioadhesive matrix tablets using waste-derived Citrus aurantifolia peel pectin as a polymer
   Scientific Reports, volume 15, Article number: 16704 (2025)
   Authors: Ebrahim Abdela Siraj, Yohannes Mulualem, Fantahun Molla, Ashagrachew Tewabe Yayehrad, Anteneh Belete
   
6. Bio-induced overproduction of heterocycloanthracin-like bacteriocin in Lysinibacillus macroides by Aspergillus austroafricanus: optimization of medium conditions and evaluation of potential applications
   BMC Biotechnology volume 25, Article number: 41 (2025)
   Authors: Philomena Edet, Maurice Ekpenyong, Atim Asitok, David Ubi, Cecilia Echa, Uwamere Edeghor, Sylvester Antai
   
7. Structural characterization, gelling properties, and beef preservation applications of pectin extracted from sweetpotato residue using a hydrothermal method
   International Journal of Biological Macromolecules, Volume 314, 2025, 144348
   Authors: Linchong Hui, Chan Zhang, Junjie Yu, Man Liu, Kunlong Yang, Ling Shen, Bingqian Hu, Jun Tian, Yong-xin Li
   
8. Calibration of soil contact parameters for planting sand shrubs in the desert regions of Inner Mongolia
   Scientific Reports volume 15, Article number: 17231 (2025)
   Authors: Zhang Nannan, Pei Chenghui, Zhang Yantang, Cui Shaoyu, Liang Lingzhi, Liu Zhigang
   
9. Development of a novel tailor-made cocktail from recombinant crude enzymes for efficient saccharification of pretreated elephant grass
   International Journal of Biological Macromolecules, 26 May 2025, 144645
   Authors: Aishwarya Aishwarya, Arun Goyal
   
10. Sustainable discharge printing of marigold-dyed cotton with eucalyptus wood ash extract and its optimisation by response surface methodology
    Coloration Technology, first published: 27 May 2025
    Authors: Harshal Patil, Devansh Chaudhari, Ashok Athalye
    
11. Chitosan-coated nanostructured lipid carriers of amantadine for nose-to-brain delivery: formulation optimization, in vitro-ex vivo characterization, and in vivo anti-parkinsonism assessment
    International Journal of Biological Macromolecules, Volume 316, Part 2, June 2025, 144497
    Authors: Archita Kapoor, Abdul Hafeez, Poonam Kushwaha, Nargis Ara

Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!

Featured Article

Implementation of the QbD Approach to the Analytical Method Development and Validation for the Estimation of the Treprostinil Injection Dosage Form by RP-HPLC
ACS Omega, 2025
Authors: Narasimha Raju Alluri, Mallikharjuna Rao Bandlamudi, Sujatha Kuppusamy, Shabna Roupal Morais

Mark's comments: This one hits the spot for me by deploying a solid central composite design, being succinct in presenting only the most relevant statistics on significance and model fits, showing compelling 3D pictures, and providing the data via a link to supplementary material. It is great to see how response surface methods done with Stat-Ease software led to a “novel, precise, sensitive, stable, and cost-effective” analytical method. Well done!

Be sure to check out this important study, and the other research listed below!

More new publications from April

1. Optimisation of process parameters for lignocellulosic biomass degradation by Pseudomonas sp. using response surface methodology
   International Journal of Biological Macromolecules, Volume 309, Part 1, May 2025, 142792
   Authors: Sunder, Sangita Yadav, Jitender Pal
   
2. Quality by Design Based Chromatography Technique Development and Validation for the Medicine Venetoclax (for Chronic Leukemia), in the Context of Impurities Including Degradation Products
   Biomedical Chromatography, 39: e70072, 02 April 2025
   Authors: Rajeshwari Dandabattina, Karuna Sree Merugu, Lova Gani Raju Bandaru, Haridasyam Sharathbabu, Rambabu Gundla, Naresh Kumar Katari
   
3. Optimization of the Drying Parameters for Plantain Chips using a Locally Made Tray Dryer: A Study on Drying Efficiency and Drying Rate Modeling using RSM
   Journal of Food Technology & Nutrition Sciences, 7(2):1-10, April 2025
   Authors: Arinzechukwu Hipolite Madukasi, Ifeanyichukwu Ugochukwu Onyenanu
   
4. Optimization of low-temperature nitrogen plasma in reducing fungi and aflatoxin human exposure through maize
   Scientific Reports volume 15, Article number: 11707 (2025)
   Authors: Hannah Mugure Kamano, Michael Wandayi Okoth, Wambui Kogi-Makau, Patrick Wafula Kuloba, Joshua Ombaka Owade & Patrick Murigu Kamau Njage
   
5. Smart nanocomposite of carbon quantum dots in double hydrogel (carboxymethyl cellulose/chitosan) for effectively adsorb and remove diquat herbicide: Characterization, thermodynamics, isotherms, kinetics, and optimizing through Box-Behnken Design
   International Journal of Biological Macromolecules Volume 309, Part 1, May 2025, 142806
   Authors: Wesam Abd El-Fattah, Ahlem Guesmi, Naoufel Ben Hamadi, Mohamed G. El-Desouky, Ashraf A. El-Bindary
   
6. Green Analytical Stability Indicating UHPLC Method for the Quantification of Related Impurities in Vonoprazan Formulation Applying Analytical Quality by Design
   Separation Science Plus, Volume 8 Issue 4, April 2025, e70032
   Authors: Ashwinkumar Matta, Raja Sundararajan
   
7. Developing a Model for Reducing Carbon Emissions of Construction Heavy Machinery Through ECO-Hauling and Collaboration
   Proceedings of the International Conference on Smart and Sustainable Built Environment (SASBE 2024), pp 618–628, 20 April 2025
   Authors: Milad Hosseinzadeh Moghaddam, Ehsan Asnaashari, Amrit Sagoo
   
8. Enhanced Antibacterial Effect of pH/Gelatinase-Responsive Florfenicol Nanogels Against Staphylococcus aureus
   International Journal of Nanomedicine, 2025;20:5193-5208
   Authors: Nannan Leng, Jinhuan Liu, Yongtao Jiang, Ning Du, Ali Sobhy Dawood, Samah Attia Algharib, Wanhe Luo
   
9. Amphiphilic mPEG-PLGA copolymer nanoparticles co-delivering colistin and niclosamide to treat colistin-resistant Gram-negative bacteria infections
   Communications Biology volume 8, Article number: 673 (2025)
   Authors: Kaifang Yi, Xilong Wang, Pengliang Li, Yanling Gao, Dandan He, Yushan Pan, Xiaoyuan Ma, Gongzheng Hu, Yajun Zhai

Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!

Featured Article

Material-sparing degradation-kinetics model for thermolabile drug stability assessment during twin-screw melt granulation – insights with gabapentin
International Journal of Pharmaceutics, Volume 674, 15 April 2025, 125421
Authors: Adwait Pradhan, Fengyuan Yang, Kapish Karan, Thomas Durig, Quyen Schwing, Brian Haight, Mark Costello, Mark Anderson, Feng Zhang

Mark's comments: "It was a pleasure to help Adwait, et al apply response surface methods (RSM) for process optimization of twin-screw melt granulation to mininimze degradation of life-enhancing drugs such as gabapentin."

Be sure to check out this important study, and the other research listed below!

More new publications from March

1. RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling
   Scientific Reports volume 15, Article number: 7922 (2025)
   Authors: Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui
   
2. A Comprehensive QbD Study on Bioadhesive Ocular Films for Improved Conjunctivitis Management: Insights from Design Expert Software
   Indian Journal of Pharmaceutical Education and Research, 2025; 59(1): 122-133
   Authors: Repollu Maddileti, Haranath Chinthaginjala
   
3. Novel Ketoconazole-Loaded Niosomal Gel with Carbamide for Enhanced Topical Delivery and Skin Hydration in Fungal Infections
   Journal of Pharmaceutical Innovation, Volume 20, article number 46, (2025)
   Authors: Prajitha Biju, Manjunath M. Shenoy, Rouchelle Tellis, Ramesh Bhat, Ranajit Das, Ashwini Prabhu, Mohammed Gulzar Ahmed, Vivek Ghate
   
4. Development of Bread from Different Protein Isolates, Sweet potatoes (Lam Ipomea batata) and Wheat Flour Blends
   Journal of Health, Wellness and Safety Research, Vol. 7 2025
   Authors: Adelakun O. E, Aliyu F
   
5. Optimization of the process of acetylation and carboxymethylation for a polysaccharide from Gastrodia elata and antioxidant and immunomodulatory activities test
   Scientific Reports volume 15, Article number: 8460 (2025)
   Authors: Hao Guan, Wenjie Yin, Xue Zhang, Fangyun Zhao, Tanling Cai, Xi Ling
   
6. Optimization of durability characteristics of engineered cementitious composites combined with titanium dioxide as a nanomaterial applying RSM modelling
   Scientific Reports volume 15, Article number: 9428 (2025)
   Authors: Naraindas Bheel, Imran Mir Chohan, Ahmed Saleh Alraeeini, Mamdooh Alwetaishi, Sahl Abdullah Waheeb, Loai Alkhattabi, Omrane Benjeddou
   
7. Optimizing Foam Properties of Egg White Powder-Based Foam System by Response Surface Methodology
   Black Sea Journal of Agriculture, Year 2025, Volume: 8 Issue: 2, 217 - 224, 15.03.2025
   Authors: Mehmet Güldane
   
8. Leaching Parameters Optimization and Kinetic Studies for Leaching of Copper from Zarara Hill Sulphide Ore in HCl, H₂SO₄ and HNO₃ Solutions
   Journal of Science Innovation and Technology Research, 2025 7(9)
   Authors: Mustapha Mukhtar, K. I. Omoniyi, Faizuan Abdullah

Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!

Mark's comment: Make sure to check out article #10, where the authors deploy response surface methods (with lots of impressive 3D plots!) to produce an eco-friendly material for civil engineering. 

1. Application of Novel Biochar Derived from Experimental Sewage Sludge Gasification as an Adsorbent for Heavy Metals Removal
   Sustainability 2025, 17(3), 997
   Authors: Domagoj Nakić, Hana Posavčić, Katarina Licht, and Dražen Vouk
   
2. Azadirachta indica Fruit Mucilage Aided Mucoadhesive Microspheres of Acyclovir for Drug Entrapment and Mucoadhesive Time Assets with Design-Expert Software
   Indian Journal of Pharmaceutical Education and Research, 2025; 59(1s): s243-s255.
   Authors: Gorantla Naresh Babu, M Menaka and Hindustan Abdul Ahad
   
3. Optimizing Water Hyacinth Compost and Chicken Manure for Enhancing Spinach Growth An Eco Friendly Approach to Sustainable Agriculture
   Indian Journal of Natural Sciences, 2024, 15(87), 976-977
   Authors: Mahmuda Parveen, Sujit Ghosh
   
4. Enhancing the tensile strength and morphology of Sansevieria trifasciata Laurentii fibers using liquid smoke and microwave treatments: an RSM approach
   Scientific Reports 15, Article number: 4420 (2025)
   Authors: Muhammad Arsyad Suyuti, Djarot B. Darmadi, Winarto, Putu Hadi Setyarini
   
5. Optimization of Biodiesel Production from Tannery Industry Fleshing Wastes Using Response Surface Methodology
   SAE Technical Paper 2025-28-0115
   Authors: Kanthasamy P, Arul Mozhi Selvan, Shanmugam P
   
6. Efficiency comparison of natural coagulants (Cactus pads and Moringa seeds) for treating textile wastewater (in the case of Kombolcha textile industry)
   Heliyon Volume 11, Issue 4, 28 February 2025
   Authors: Getahun Demeke Worku, Shimeles Nigussie Abate
   
7. Physico-chemical Characterisation of Ultrasound Processed Finger Millet Malt
   Asian Journal of Dairy and Food Research 14 February 2025
   Authors: Almas Begum Adoni, Madhava Mondru, Kaliramesh Siliveru, Vishnuvardhan Sidlagatta, Sandeep Raja Donepudi, Swapna Motamarri
   
8. Preparation of Gluten Free Cookie using Chestnut and Foxnut Flour Blend: Composition Optimization Through Response Surface Methodology
   Asian Journal of Dairy and Food Research Volume 44 Issue 1 (February 2025) : 84-91
   Authors: Divya Singh Chauhan, Apoorva Behari Lal, Anto Pradeep Raja Charles, Amit Pratap Singh, Ashish Khare, Pranav Vashisht
   
9. Optimization of Biochar Production from Cassava Peels: An Application of Response Surface Methodology
   Archives of Advanced Engineering Science 1-9
   Authors: Timothy Adekanye, Abiodun Okunola, Adeolu Adediran, Afolabi Tokunbo Yemisi, Aisha Aderibigbe
   
10. Investigations on mechanical and stress strain characteristics of geopolymer concrete reinforced with glass fibers
    Scientific Reports volume 15, Article number: 6335 (2025)
    Authors: Thunuguntla Chaitanya Srikrishna, Venkatesh Noolu, B. Sudheer Kumar Reddy, George Uwadiegwu Alaneme, Ravella Durga Prasad & M. VishnuPriyan
    
11. Study on hydration mechanism and ratio optimization of slag powder modified high-water material
    Scientific Reports volume 15, Article number: 6175 (2025)
    Authors: Xiang Ma, Chenyang Liu, Liwei Zhai, Shengrong Xie, Chaowen Wu & Jian Yang
    
12. Extraction and purification of total flavonoids from Zanthoxylum planispinum Var. Dintanensis leaves and effect of altitude on total flavonoids content
    Scientific Reports volume 15, Article number: 7080 (2025)
    Authors: Jiyue Wang, Xianqi Huang, Zhenyu Chen, Nian Chen, Mingli Yang, Chenggang Liang, Yanghua Yu & Denghong Shi
    
13. Preparation and characterization of inorganic foam modified with nano-magnesium hydroxide for inhibiting coal spontaneous combustion
    Physics of Fluids 37, 022152 (2025)
    Authors: Jingxia Tang, Jiawen Cai, Shengqiang Yang, Zhaoyang Yu, Kexin Chen, Xincheng Hu
    
14. Experimental approach and assessment of Zr conversion coatings on Al alloy using response surface methodology
    Corrosion Science, Volume 249, 2025, 112824
    Authors: Ana Kraš, Davorin Kramar, Ingrid Milošev