Stat-Ease Blog
Categories
July Publication Roundup
Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!
Featured Articles
Microwave-assisted extraction of bioactive compounds from Urtica dioica using solvent-based process optimization and characterization
Scientific Reports volume 15, Article number: 25375 (2025)
Authors: Anjali Sahal, Afzal Hussain, Ritesh Mishra, Sakshi Pandey, Ankita Dobhal, Waseem Ahmad, Vinod Kumar, Umesh Chandra Lohani, Sanjay Kumar
Mark's comments: Kudos to this team for deploying a Box-Behnken response-surface-method design--convenient by only requiring 3 levels of each of their 3 factors (power, time and sample-to-solvent ratio)--to optimize their process. Given all the raw data I was able to easily copy it out and import it into my Stat-Ease software and check into the modeling--no major issues uncovered. The authors did well by diagnosing residuals and making use of our numerical optimization tools to find the most desirable factor combination for their multiple-response goals.
Be sure to check out this important study, and the other research listed below!
More new publications from July
- Improving the heterotrophic media of three Chlorella vulgaris mutants toward optimal color, biomass and protein productivity
Scientific Reports volume 15, Article number: 23325 (2025)
Authors: Mafalda Trovão, Miguel Cunha, Gonçalo Espírito Santo, Humberto Pedroso, Ana Reis, Ana Barros, Nádia Correia, Lisa Schüler, Monya Costa, Sara Ferreira, Helena Cardoso, Márcia Ventura, João Varela, Joana Silva, Filomena Freitas, Hugo Pereira - Calibration and establishment for the discrete element simulation parameters of pepper stem during harvest period
Scientific Reports volume 15, Article number: 21143 (2025)
Authors: Jiaxuan Yang, Jin Lei, Xinyan Qin, Zhi Wang, Jianglong Zhang, Lijian Lu - Design Expert Software Being Used to Explore the Factors Affecting the “Water Garden”
American Journal of Analytical Chemistry, 16, 107-116
Authors: Zelin Miu, Yichen Lu - Quality improvement of recycled carbon black from waste tire pyrolysis for replacing carbon black N330
Scientific Reports volume 15, Article number: 23726 (2025)
Authors: Tawan Laithong, Tarinee Nampitch, Peerapon Ourapeepon, Natacha Phetyim - Development and in vitro characterization of embelin bilosomes for enhanced oral bioavailability
Journal of Research in Pharmacy, Year 2025, Volume: 29 Issue: 4, 1616 - 1626, 05.07.2025
Authors: Shreya Firake Devanshi Pethani Jeet Patil Avinash Bhujbal Rahul Gondake Dhanashree Sanap , Sneha Agrawal - Performance optimization and mechanism research of C20 coal gangue concrete based on response surface and water resistance
AIP Advances, 15, 075316 (2025)
Authors: Yong Cui, Xiwen Yin, Qiuge Yu - Multi-objective optimization of boiler combustion efficiency and emissions using genetic algorithm and recurrent neural network in 660-MW coal-fired power plant
Eastern-European Journal of Enterprise Technologies, 3(8 (135), 23–33
Authors: Mohamad Arwan Efendy, Ahmad Syihan Auzani, Sholahudin Sholahudin - Optimization and characterization of polyhydroxybutyrate produced by Vreelandella piezotolerans using orange peel waste
Scientific Reports volume 15, Article number: 25873 (2025)
Authors: Mahmoud H. Hendy, Amr M. Shehabeldine, Amr H. Hashem, Ahmed F. El-Sayed, Hussein H El-Sheikh - Multi-functional electrodialysis process to treat hyper-saline reverse osmosis brine: producing high value-added HCl, NaOH and energy consumption calculation
Environmental Sciences Europe volume 37, Article number: 121 (2025)
Authors: Haia M. Elsayd, Gamal K. Hassan, Ahmed A. Affy, M. Hanafy, Tamer S. Ahmed - Quality by Design-Based Method for Simultaneous Determination of Glimepiride and Lovastatin in Self-Nano Emulsifying Drug Delivery System
Separation Science Plus, 8: e70097
Authors: Priyanka Paul, Raj Kamal, Thakur Gurjeet Singh, Ankit Awasthi, Rohit Bhatia - Sustainable Adsorbents for Wastewater Treatment: Template-Free Mesoporous Silica from Coal Fly Ash
Chemical Engineering & Technology, 48: e70077
Authors: Thapelo Manyepedza, Emmanuel Gaolefufa, Gaone Koodirile, Dr. Isaac N. Beas, Dr. Joshua Gorimbo, Bakang Modukanele, Dr. Moses T. Kabomo
June 2025 Publication Roundup
Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!
Featured Article
Orange-Fleshed Sweet Potatoes, Grain Amaranth, Biofortified Beans, and Maize Composite Flour Formulation Optimization and Product Characterization
Food Science and Nutrition, Volume 13, Issue 6. June 2025.
Authors: Julius Byamukama, Robert Mugabi, Dorothy Nakimbugwe, John Muyonga
Mark's comments: "It's good to see response surface methods for optimization of food recipes via mixture design. I appreciate publications that include all the data needed to assess the predictive modeling. Kudus to EU for funding research like this that alleviates malnutrition in vulnerable populations."
Be sure to check out this important study, and the other research listed below!
More new publications from June
- Optimization and induction effect evaluation of complex inducer of Aquilaria sinensis based on factorial design
Scientific Reports, volume 15, Article number: 19656 (2025)
Authors: Qiuyue Ding, Baoyi Qin, Shimin Deng, Jie Chen, Ziwei Liu, Weiping Zhou, Xiaoying Chen, Weimin Zhang, Xin Zhou, Xiaoxia Gao - Adsorption of crystal violet using thiazolium ionic liquid-crosslinked alginate hydrogels: Modelling using Box-Behnken experimental design
International Journal of Biological Macromolecules, Volume 318, Part 1, July 2025, 144951
Authors: Merve Ceylan, Jülide Hızal, Elif Nur Özer, Ivaylo Tankov, Rumyana Yankova - High-Performance Ultrathin Membrane with Molecular Arrangement Ordered for Proton Exchange Membrane
ACS Applied Polymer Materials, published June 10, 2025
Authors: Yuqing Zhang, Ailing Zhang, Kaixiang Zhou, Yongjiang Li - Impact of addition of polyvinyl chloride on the properties of clayey soil using experimental approach and optimization for geotechnical engineering applications
Scientific Reports, volume 15, Article number: 19901 (2025)
Authors: Ghania Boukhatem, Said Berdoudi, Messaouda Bencheikh, Mohammed Benzerara, Mehmet Serkan Kırgız, N. Nagaprasad, Krishnaraj Ramaswamy - Copper Corrosion in Blended Diesel-Biodiesel: Corrosion Rate Evaluation and Characterization
Chemical Engineering & Technology, e70053, 12 June 2025
Authors: Lekan Taofeek Popoola, Celestine Chidi Nwogbu, Usman Taura, Yuli Panca Asmara, Alfred Ogbodo Agbo, Paul C. Okonkwo - The Effects of Novel Thymoquinone-Loaded Nanovesicles as a Promising Avenue to Modulate Autism Associated Dysregulation by Restoring Oxidative Stress in Autism in Mice
International Journal of Nanomedicine, 24 June 2025 Volume 2025:20 Pages 8041—8061
Authors: Nermin Eissa, Jana K Alwattar, Petrilla Jayaprakash, Dana Chkier, Aala Osama Ahmed, Anum Ahmed, Rameen Rizwan, Sulthan Mujeeb, Mohamad Rahal, Bassem Sadek
May 2025 Publication Roundup
Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!
Featured Article
Enhanced 4-chlorophenol adsorption from aqueous solution using eco-friendly nanocomposite
Ecological Engineering & Environmental Technology, 26(5), pp.174-189
Authors: Fadia A. Sulaiman, Rasha Khalid Sabri Mhemid, Noor A. Mohammed
Mark's comments: It is great to see the application of response surface methods (RSM) to reduce the release of toxic chlorophenols to our environment, particularly via such an eco-friendly process utilizing a natural polymer--xanthan gum. The 3D graphics are compelling and well supported by the reported statistics. I also appreciate that all the raw data is including, making it possible for me to reproduce the results.
Be sure to check out this important study, and the other research listed below!
More new publications from May
- Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
Drug Design, Development and Therapy, 2025;19:3715-3734
Authors: Mujtaba MA, Rashid MA, Alhamhoom Y, Gangane P, Jagtap MJ, Akbar MJ, Wathore SA, Kaleem M, Elhassan GO, Khalid M - Design of Experiments Approach for the Development of a Validated UPLC-Q-ToF/MS Method to Quantitate Soy-Derived Bioactive Peptide Lunasin in Rabbit Plasma: Application to a Pharmacokinetic Study
Biomedical Chromatography, 2025, 39: e70098
Authors: Kowmudi, G., Anoop, K., Varshini, M., Nagappan, K., Konanki, S., Praveen, T - Development of a Stability-Indicating RP-HPLC Method for Pioglitazone in Cubosomal and Biological Matrices: A Quality by Design-Driven, Lean Six Sigma, and Green Chemistry Approach
Separation Science Plus, 2025, 8: e70055
Authors: Vaibhavi D. Torgal, Vinayak Mastiholimath, Rahul Koli - Optimization process of coffee pulp wines combined with the artificial neural network and response surface methodology
Scientific Reports, volume 15, Article number: 16684 (2025)
Authors: Rongsuo Hu, Fei Xu, Liyan Zhao, Wenjiang Dong - Formulation optimization of furosemide floating-bioadhesive matrix tablets using waste-derived Citrus aurantifolia peel pectin as a polymer
Scientific Reports, volume 15, Article number: 16704 (2025)
Authors: Ebrahim Abdela Siraj, Yohannes Mulualem, Fantahun Molla, Ashagrachew Tewabe Yayehrad, Anteneh Belete - Bio-induced overproduction of heterocycloanthracin-like bacteriocin in Lysinibacillus macroides by Aspergillus austroafricanus: optimization of medium conditions and evaluation of potential applications
BMC Biotechnology volume 25, Article number: 41 (2025)
Authors: Philomena Edet, Maurice Ekpenyong, Atim Asitok, David Ubi, Cecilia Echa, Uwamere Edeghor, Sylvester Antai - Structural characterization, gelling properties, and beef preservation applications of pectin extracted from sweetpotato residue using a hydrothermal method
International Journal of Biological Macromolecules, Volume 314, 2025, 144348
Authors: Linchong Hui, Chan Zhang, Junjie Yu, Man Liu, Kunlong Yang, Ling Shen, Bingqian Hu, Jun Tian, Yong-xin Li - Calibration of soil contact parameters for planting sand shrubs in the desert regions of Inner Mongolia
Scientific Reports volume 15, Article number: 17231 (2025)
Authors: Zhang Nannan, Pei Chenghui, Zhang Yantang, Cui Shaoyu, Liang Lingzhi, Liu Zhigang - Development of a novel tailor-made cocktail from recombinant crude enzymes for efficient saccharification of pretreated elephant grass
International Journal of Biological Macromolecules, 26 May 2025, 144645
Authors: Aishwarya Aishwarya, Arun Goyal - Sustainable discharge printing of marigold-dyed cotton with eucalyptus wood ash extract and its optimisation by response surface methodology
Coloration Technology, first published: 27 May 2025
Authors: Harshal Patil, Devansh Chaudhari, Ashok Athalye - Chitosan-coated nanostructured lipid carriers of amantadine for nose-to-brain delivery: formulation optimization, in vitro-ex vivo characterization, and in vivo anti-parkinsonism assessment
International Journal of Biological Macromolecules, Volume 316, Part 2, June 2025, 144497
Authors: Archita Kapoor, Abdul Hafeez, Poonam Kushwaha, Nargis Ara
Publication Roundup April 2025
Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!
Featured Article
Implementation of the QbD Approach to the Analytical Method Development and Validation for the Estimation of the Treprostinil Injection Dosage Form by RP-HPLC
ACS Omega, 2025
Authors: Narasimha Raju Alluri, Mallikharjuna Rao Bandlamudi, Sujatha Kuppusamy, Shabna Roupal Morais
Mark's comments: This one hits the spot for me by deploying a solid central composite design, being succinct in presenting only the most relevant statistics on significance and model fits, showing compelling 3D pictures, and providing the data via a link to supplementary material. It is great to see how response surface methods done with Stat-Ease software led to a “novel, precise, sensitive, stable, and cost-effective” analytical method. Well done!
Be sure to check out this important study, and the other research listed below!
More new publications from April
- Optimisation of process parameters for lignocellulosic biomass degradation by Pseudomonas sp. using response surface methodology
International Journal of Biological Macromolecules, Volume 309, Part 1, May 2025, 142792
Authors: Sunder, Sangita Yadav, Jitender Pal - Quality by Design Based Chromatography Technique Development and Validation for the Medicine Venetoclax (for Chronic Leukemia), in the Context of Impurities Including Degradation Products
Biomedical Chromatography, 39: e70072, 02 April 2025
Authors: Rajeshwari Dandabattina, Karuna Sree Merugu, Lova Gani Raju Bandaru, Haridasyam Sharathbabu, Rambabu Gundla, Naresh Kumar Katari - Optimization of the Drying Parameters for Plantain Chips using a Locally Made Tray Dryer: A Study on Drying Efficiency and Drying Rate Modeling using RSM
Journal of Food Technology & Nutrition Sciences, 7(2):1-10, April 2025
Authors: Arinzechukwu Hipolite Madukasi, Ifeanyichukwu Ugochukwu Onyenanu - Optimization of low-temperature nitrogen plasma in reducing fungi and aflatoxin human exposure through maize
Scientific Reports volume 15, Article number: 11707 (2025)
Authors: Hannah Mugure Kamano, Michael Wandayi Okoth, Wambui Kogi-Makau, Patrick Wafula Kuloba, Joshua Ombaka Owade & Patrick Murigu Kamau Njage - Smart nanocomposite of carbon quantum dots in double hydrogel (carboxymethyl cellulose/chitosan) for effectively adsorb and remove diquat herbicide: Characterization, thermodynamics, isotherms, kinetics, and optimizing through Box-Behnken Design
International Journal of Biological Macromolecules Volume 309, Part 1, May 2025, 142806
Authors: Wesam Abd El-Fattah, Ahlem Guesmi, Naoufel Ben Hamadi, Mohamed G. El-Desouky, Ashraf A. El-Bindary - Green Analytical Stability Indicating UHPLC Method for the Quantification of Related Impurities in Vonoprazan Formulation Applying Analytical Quality by Design
Separation Science Plus, Volume 8 Issue 4, April 2025, e70032
Authors: Ashwinkumar Matta, Raja Sundararajan - Developing a Model for Reducing Carbon Emissions of Construction Heavy Machinery Through ECO-Hauling and Collaboration
Proceedings of the International Conference on Smart and Sustainable Built Environment (SASBE 2024), pp 618–628, 20 April 2025
Authors: Milad Hosseinzadeh Moghaddam, Ehsan Asnaashari, Amrit Sagoo - Enhanced Antibacterial Effect of pH/Gelatinase-Responsive Florfenicol Nanogels Against Staphylococcus aureus
International Journal of Nanomedicine, 2025;20:5193-5208
Authors: Nannan Leng, Jinhuan Liu, Yongtao Jiang, Ning Du, Ali Sobhy Dawood, Samah Attia Algharib, Wanhe Luo - Amphiphilic mPEG-PLGA copolymer nanoparticles co-delivering colistin and niclosamide to treat colistin-resistant Gram-negative bacteria infections
Communications Biology volume 8, Article number: 673 (2025)
Authors: Kaifang Yi, Xilong Wang, Pengliang Li, Yanling Gao, Dandan He, Yushan Pan, Xiaoyuan Ma, Gongzheng Hu, Yajun Zhai
Publication Roundup March 2025
Here's the latest Publication Roundup! In these monthly posts, we'll feature recent papers that cited Design-Expert® or Stat-Ease® 360 software. Please submit your paper to us if you haven't seen it featured yet!
Featured Article
Material-sparing degradation-kinetics model for thermolabile drug stability assessment during twin-screw melt granulation – insights with gabapentin
International Journal of Pharmaceutics, Volume 674, 15 April 2025, 125421
Authors: Adwait Pradhan, Fengyuan Yang, Kapish Karan, Thomas Durig, Quyen Schwing, Brian Haight, Mark Costello, Mark Anderson, Feng Zhang
Mark's comments: "It was a pleasure to help Adwait, et al apply response surface methods (RSM) for process optimization of twin-screw melt granulation to mininimze degradation of life-enhancing drugs such as gabapentin."
Be sure to check out this important study, and the other research listed below!
More new publications from March
- RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling
Scientific Reports volume 15, Article number: 7922 (2025)
Authors: Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui - A Comprehensive QbD Study on Bioadhesive Ocular Films for Improved Conjunctivitis Management: Insights from Design Expert Software
Indian Journal of Pharmaceutical Education and Research, 2025; 59(1): 122-133
Authors: Repollu Maddileti, Haranath Chinthaginjala - Novel Ketoconazole-Loaded Niosomal Gel with Carbamide for Enhanced Topical Delivery and Skin Hydration in Fungal Infections
Journal of Pharmaceutical Innovation, Volume 20, article number 46, (2025)
Authors: Prajitha Biju, Manjunath M. Shenoy, Rouchelle Tellis, Ramesh Bhat, Ranajit Das, Ashwini Prabhu, Mohammed Gulzar Ahmed, Vivek Ghate - Development of Bread from Different Protein Isolates, Sweet potatoes (Lam Ipomea batata) and Wheat Flour Blends
Journal of Health, Wellness and Safety Research, Vol. 7 2025
Authors: Adelakun O. E, Aliyu F - Optimization of the process of acetylation and carboxymethylation for a polysaccharide from Gastrodia elata and antioxidant and immunomodulatory activities test
Scientific Reports volume 15, Article number: 8460 (2025)
Authors: Hao Guan, Wenjie Yin, Xue Zhang, Fangyun Zhao, Tanling Cai, Xi Ling - Optimization of durability characteristics of engineered cementitious composites combined with titanium dioxide as a nanomaterial applying RSM modelling
Scientific Reports volume 15, Article number: 9428 (2025)
Authors: Naraindas Bheel, Imran Mir Chohan, Ahmed Saleh Alraeeini, Mamdooh Alwetaishi, Sahl Abdullah Waheeb, Loai Alkhattabi, Omrane Benjeddou - Optimizing Foam Properties of Egg White Powder-Based Foam System by Response Surface Methodology
Black Sea Journal of Agriculture, Year 2025, Volume: 8 Issue: 2, 217 - 224, 15.03.2025
Authors: Mehmet Güldane - Leaching Parameters Optimization and Kinetic Studies for Leaching of Copper from Zarara Hill Sulphide Ore in HCl, H₂SO₄ and HNO₃ Solutions
Journal of Science Innovation and Technology Research, 2025 7(9)
Authors: Mustapha Mukhtar, K. I. Omoniyi, Faizuan Abdullah